Ki Summary

Reaction Details

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Target

Interleukin-1 receptor-associated kinase 4

Ligand

BDBM643829

Substrate/Competitor

n/a

Meas. Tech.

Potency of IRAK4 Inhibitor Compounds in IRAK4 Enzyme Assay

IC50

0.700±n/a nM

Citation

Terstiege, I; Schiesser, S; Xue, Y; Chang, H; Berggren, AI Substituted indazoles as IRAK4 inhibitors US Patent US11866405 Publication Date 1/9/2024

More Info.:

Get all data from this article, Assay Method

Interleukin-1 receptor-associated kinase 4

Name:

Interleukin-1 receptor-associated kinase 4

Synonyms:

Type:

Protein

Mol. Mass.:

51519.08

Organism:

Homo sapiens (Human)

Description:

Q9NWZ3

Residue:

460

Sequence:

MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS

BDBM643829

n/a

Name

BDBM643829

Synonyms:

US11866405, Example 97

Type

Small organic molecule

Emp. Form.

C27H31N7O4

Mol. Mass.

517.5795

SMILES

COc1cc2nn(cc2cc1C(=O)Nc1cnn2cccnc12)C1CC[C@@H](CC1)N(C)C(=O)[C@H]1C[C@H](O)C1 |r,wU:33.37,wD:26.33,35.40,(5.74,-3.24,;5.74,-1.7,;4.4,-.93,;3.07,-1.7,;1.73,-.93,;.27,-1.4,;-.64,-.16,;.27,1.09,;1.73,.61,;3.07,1.38,;4.4,.61,;5.74,1.38,;5.74,2.92,;7.07,.61,;8.4,1.38,;8.56,2.92,;10.07,3.24,;10.84,1.9,;12.35,1.58,;12.82,.12,;11.79,-1.03,;10.29,-.71,;9.81,.76,;-2.18,-.16,;-2.94,-1.49,;-4.49,-1.49,;-5.25,-.16,;-4.49,1.18,;-2.94,1.18,;-6.79,-.16,;-7.56,1.18,;-7.56,-1.49,;-6.79,-2.82,;-9.1,-1.49,;-10.19,-2.58,;-11.28,-1.49,;-12.82,-1.49,;-10.19,-.4,)|

Structure