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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM50599226 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Potency of IRAK4 Inhibitor Compounds in IRAK4 Enzyme Assay | ||
| IC50 | <0.030±n/a nM | ||
| Citation |  Terstiege, I; Schiesser, S; Xue, Y; Chang, H; Berggren, AI Substituted indazoles as IRAK4 inhibitors US Patent US11866405 Publication Date 1/9/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
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| BDBM50599226 | |||
| n/a | |||
| Name | BDBM50599226 | ||
| Synonyms: | CHEMBL5201062 | US11866405, Example 100 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H33N7O4 | ||
| Mol. Mass. | 543.6168 | ||
| SMILES | CO[C@H]1C[C@@H](C1)Oc1cc2nn(cc2cc1C(=O)Nc1cnc2cccnn12)C1CCC2(CN(C2)C(C)=O)CC1 |r,wU:4.6,wD:2.1,(5.55,-5.49,;4.22,-4.72,;4.22,-3.18,;5.31,-2.09,;4.2,-.98,;3.11,-2.07,;4.2,.56,;2.87,1.33,;1.54,.57,;.21,1.32,;-1.25,.85,;-2.16,2.09,;-1.25,3.34,;.21,2.86,;1.54,3.63,;2.87,2.87,;4.2,3.64,;4.2,5.18,;5.53,2.87,;6.87,3.64,;7.03,5.17,;8.53,5.49,;9.3,4.15,;10.81,3.83,;11.28,2.37,;10.25,1.22,;8.75,1.54,;8.27,3.01,;-3.7,2.09,;-4.47,.76,;-6.01,.76,;-6.78,2.09,;-7.88,.99,;-8.97,2.08,;-7.87,3.18,;-10.51,2.08,;-11.28,.74,;-11.28,3.41,;-6.01,3.43,;-4.47,3.43,)| | ||
| Structure | 
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