Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Interleukin-1 receptor-associated kinase 4 | ||
Ligand | BDBM643839 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Potency of IRAK4 Inhibitor Compounds in IRAK4 Enzyme Assay | ||
IC50 | 0.700±n/a nM | ||
Citation | Terstiege, I; Schiesser, S; Xue, Y; Chang, H; Berggren, AI Substituted indazoles as IRAK4 inhibitors US Patent US11866405 Publication Date 1/9/2024 | ||
More Info.: | Get all data from this article, Assay Method | ||
Interleukin-1 receptor-associated kinase 4 | |||
Name: | Interleukin-1 receptor-associated kinase 4 | ||
Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
Type: | Protein | ||
Mol. Mass.: | 51519.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9NWZ3 | ||
Residue: | 460 | ||
Sequence: |
| ||
BDBM643839 | |||
n/a | |||
Name | BDBM643839 | ||
Synonyms: | US11866405, Example 102 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H23N9O2 | ||
Mol. Mass. | 457.4878 | ||
SMILES | COc1cc2nn(cc2cc1C(=O)Nc1cnc2cccnn12)[C@H]1CC[C@@H](CC1)n1ccnn1 |r,wU:26.33,wD:23.26,(3.91,-3.24,;3.91,-1.7,;2.57,-.93,;1.24,-1.7,;-.09,-.93,;-1.56,-1.4,;-2.46,-.16,;-1.56,1.09,;-.09,.61,;1.24,1.38,;2.57,.61,;3.91,1.38,;3.91,2.92,;5.24,.61,;6.57,1.38,;6.74,2.92,;8.24,3.24,;9.01,1.9,;10.52,1.58,;10.99,.12,;9.96,-1.03,;8.46,-.71,;7.98,.76,;-4,-.16,;-4.77,1.18,;-6.31,1.18,;-7.08,-.16,;-6.31,-1.49,;-4.77,-1.49,;-8.62,-.16,;-9.53,-1.4,;-10.99,-.93,;-10.99,.61,;-9.53,1.09,)| | ||
Structure |