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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM643852 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Potency of IRAK4 Inhibitor Compounds in IRAK4 Enzyme Assay | ||
| IC50 | 0.600±n/a nM | ||
| Citation |  Terstiege, I; Schiesser, S; Xue, Y; Chang, H; Berggren, AI Substituted indazoles as IRAK4 inhibitors US Patent US11866405 Publication Date 1/9/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM643852 | |||
| n/a | |||
| Name | BDBM643852 | ||
| Synonyms: | US11866405, Example 46 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H28N6O3 | ||
| Mol. Mass. | 472.5389 | ||
| SMILES | OC1C[C@@]2(C1)CC[C@@H](CC2)n1cc2cc(C(=O)Nc3cnn4cccnc34)c(OC3CC3)cc2n1 |r,wU:3.2,wD:7.11,(-10.67,-7.73,;-9.58,-6.64,;-8.49,-5.55,;-7.41,-6.64,;-8.49,-7.73,;-6.64,-5.31,;-5.1,-5.31,;-4.33,-6.64,;-5.1,-7.97,;-6.64,-7.97,;-2.79,-6.64,;-1.88,-5.39,;-.42,-5.87,;.92,-5.1,;2.25,-5.87,;3.59,-5.1,;3.59,-3.56,;4.92,-5.87,;6.25,-5.1,;6.41,-3.57,;7.92,-3.25,;8.69,-4.58,;10.2,-4.9,;10.67,-6.37,;9.64,-7.51,;8.14,-7.19,;7.66,-5.73,;2.25,-7.41,;3.59,-8.18,;3.59,-9.72,;2.82,-11.05,;4.36,-11.05,;.92,-8.18,;-.42,-7.41,;-1.88,-7.89,)| | ||
| Structure | 
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