Ki Summary

Reaction Details

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Target

Interleukin-1 receptor-associated kinase 4

Ligand

BDBM643863

Substrate/Competitor

n/a

Meas. Tech.

Potency of IRAK4 Inhibitor Compounds in IRAK4 Enzyme Assay

IC50

0.700±n/a nM

Citation

Terstiege, I; Schiesser, S; Xue, Y; Chang, H; Berggren, AI Substituted indazoles as IRAK4 inhibitors US Patent US11866405 Publication Date 1/9/2024

More Info.:

Get all data from this article, Assay Method

Interleukin-1 receptor-associated kinase 4

Name:

Interleukin-1 receptor-associated kinase 4

Synonyms:

Type:

Protein

Mol. Mass.:

51519.08

Organism:

Homo sapiens (Human)

Description:

Q9NWZ3

Residue:

460

Sequence:

MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS

BDBM643863

n/a

Name

BDBM643863

Synonyms:

US11866405, Example 114

Type

Small organic molecule

Emp. Form.

C28H33N7O4

Mol. Mass.

531.6061

SMILES

COc1cc2nn(cc2cc1C(=O)Nc1cnn2cccnc12)[C@@H]1CC[C@@H](CC1)N(C)C(=O)[C@@H]1CC[C@@H](O)C1 |r,wU:33.37,wD:23.26,26.33,36.41,(5.61,-9.99,;5.61,-8.45,;4.27,-7.68,;2.94,-8.45,;1.61,-7.68,;.14,-8.16,;-.76,-6.91,;.14,-5.66,;1.61,-6.14,;2.94,-5.37,;4.27,-6.14,;5.61,-5.37,;5.61,-3.83,;6.94,-6.14,;8.27,-5.37,;8.44,-3.84,;9.94,-3.52,;10.71,-4.85,;12.22,-5.17,;12.69,-6.64,;11.66,-7.78,;10.16,-7.46,;9.68,-6,;-2.3,-6.91,;-3.07,-8.24,;-4.61,-8.24,;-5.38,-6.91,;-4.61,-5.58,;-3.07,-5.58,;-6.92,-6.91,;-7.69,-5.58,;-7.69,-8.24,;-6.92,-9.58,;-9.23,-8.24,;-10.24,-7.08,;-11.66,-7.68,;-11.53,-9.21,;-12.69,-10.22,;-10.03,-9.56,)|

Structure