| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
|---|
| Ligand | BDBM645833 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | MALT1 Protease Assay 1 |
|---|
| IC50 | <10±n/a nM |
|---|
| Citation |  Feng, S; Lawrenz, M; Krilov, G; Placzek, A; Nie, Z; Trzoss, L; Trzoss, M; Tang, H; Lagiakos, HR CYCLIC COMPOUNDS AND METHODS OF USING SAME US Patent US20240018157 Publication Date 1/18/2024 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
|---|
| Name: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
|---|
| Synonyms: | MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 92257.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UDY8 |
|---|
| Residue: | 824 |
|---|
| Sequence: | MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL
AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ
LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP
GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD
SKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK
APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF
GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL
KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH
LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI
QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS
KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG
LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS
RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
|
|
|
|---|
| BDBM645833 |
|---|
| n/a |
|---|
| Name | BDBM645833 |
|---|
| Synonyms: | (R)-2-chloro-N-(5-(difluoromethyl)-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-8-methyl-8-(trifluoromethyl)-7,8-dihydro-6H-pyrazolo[1,5-a]pyrrolo[2,3-e]pyrimidine-6-carboxamide | US20240018157, Example 35 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H13ClF5N9O |
|---|
| Mol. Mass. | 513.811 |
|---|
| SMILES | C[C@]1(CN(C(=O)Nc2cnc(c(c2)C(F)F)-n2nccn2)c2cnc3cc(Cl)nn3c12)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
