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TargetProtein-arginine deiminase type-4
LigandBDBM646114
Substrate/Competitorn/a
Meas. Tech.In Vitro PAD4 BAEE Biochemical Assay
IC50 28.4±n/a nM
Citation Byun, DHCai, ZRCanales, EYDebien, LPHansen, TRHuang, RJansa, PLee, RALoyer-Drew, JAMcFadden, RMitchell, MLPyun, HSaito, RDSangi, MSSchrier, AJShatskikh, METaylor, JGVan Veldhuizen, JJXu, L Inhibitors of peptidylarginine deiminases US Patent US11878965 Publication Date 1/23/2024
More Info.:Get all data from this article,  Assay Method
 
Protein-arginine deiminase type-4
Name:Protein-arginine deiminase type-4
Synonyms:PAD4 | PADI4 | PADI4_HUMAN | PADI5 | PDI5
Type:Enzyme Catalytic Domain
Mol. Mass.:74078.90
Organism:Homo sapiens (Human)
Description:gi_216548487
Residue:663
Sequence:
MAQGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIAHGPPAKK
KSTGSSTWPLDPGVEVTLTMKVASGSTGDQKVQISYYGPKTPPVKALLYLTGVEISLCAD
ITRTGKVKPTRAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDM
SLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATRGKLSSKCSVVLGPKWPSHYLMV
PGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTP
NTQPPQEVYACSIFENEDFLKSVTTLAMKAKCKLTICPEEENMDDQWMQDEMEIGYIQAP
HKTLPVVFDSPRNRGLKEFPIKRVMGPDFGYVTRGPQTGGISGLDSFGNLEVSPPVTVRG
KEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVP
APDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNS
FVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPK
PFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHCGTNVRRKPFSFKWWN
MVP
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  Blast E-value cutoff:
BDBM646114
n/a
NameBDBM646114
Synonyms:((R)-3-aminopiperidin-1-yl)(1- cyclopropyl-2-(1- (cyclopropylmethyl)-6-((S)-3- methyl-1,1-dioxido-1,2- thiazinan-2-yl)-1H- pyrrolo[2,3-b]pyridin-2-yl)-1H- benzo[d]imidazol-5-yl) methanone | US11878965, Example 99
TypeSmall organic molecule
Emp. Form.C32H39N7O3S
Mol. Mass.601.762
SMILESC[C@H]1CCCS(=O)(=O)N1c1ccc2cc(-c3nc4cc(ccc4n3C3CC3)C(=O)N3CCC[C@@H](N)C3)n(CC3CC3)c2n1 |r|
Structure
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