Ki Summary

Reaction Details

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Target

GTPase KRas [G12D]

Ligand

BDBM629325

Substrate/Competitor

n/a

Meas. Tech.

KRAS G12D LoEnz Biochemical Assay

IC50

0.120±n/a nM

Citation

Landry, ML; Nilewski, C; Siu, M; Villemure, E; Wang, Y; Wei, B; Ashley, MA; Do, S; Gazzard, LJ; Green, SA AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF US Patent US20240025919 Publication Date 1/25/2024

More Info.:

Get all data from this article, Assay Method

GTPase KRas [G12D]

Name:

GTPase KRas [G12D]

Synonyms:

GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

21713.12

Organism:

Homo sapiens (Human)

Description:

P01116[G12D]

Residue:

189

Sequence:

MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM

BDBM629325

n/a

Name

BDBM629325

Synonyms:

Compound 5 (5-fluoro-4-((5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)naphthalen-2-ol) | Compound 5 (5-fluoro-4-((5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)naphthalen-2-ol) and Compound 6 (6-chloro-5-fluoro-4-((5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)naphthalen-2-ol) | US20230339981, Example 5 | US20240025919, Compound 1

Type

Small organic molecule

Emp. Form.

C32H31F3N6O3

Mol. Mass.

604.6221

SMILES

Oc1cc(-c2nc3OC[C@@H]4[C@@H]5CC[C@H](CN4c4nc(OC[C@@]67CCCN6C[C@H](F)C7)nc(c2F)c34)N5)c2c(F)cccc2c1 |r|

Structure