Reaction Details |
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Target | GTPase KRas [G12D] |
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Ligand | BDBM647789 |
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Substrate/Competitor | n/a |
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Meas. Tech. | KRAS G12D LoEnz Biochemical Assay |
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IC50 | 0.138±n/a nM |
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Citation | Landry, ML; Nilewski, C; Siu, M; Villemure, E; Wang, Y; Wei, B; Ashley, MA; Do, S; Gazzard, LJ; Green, SA AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF US Patent US20240025919 Publication Date 1/25/2024 |
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More Info.: | Get all data from this article, Assay Method |
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GTPase KRas [G12D] |
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Name: | GTPase KRas [G12D] |
Synonyms: | GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 21713.12 |
Organism: | Homo sapiens (Human) |
Description: | P01116[G12D] |
Residue: | 189 |
Sequence: | MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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BDBM647789 |
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n/a |
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Name | BDBM647789 |
Synonyms: | US20240025919, Compound 16 |
Type | Small organic molecule |
Emp. Form. | C31H34F5N7O2 |
Mol. Mass. | 631.6394 |
SMILES | C[C@@H]1Oc2nc(c(F)c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5CC[C@H](N5)[C@@H]14)c23)-c1cc(N)cc(C)c1C(F)(F)F |r| |
Structure |
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