| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas [G12D] |
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| Ligand | BDBM647890 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | KRAS G12D LoEnz Biochemical Assay |
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| IC50 | 0.110±n/a nM |
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| Citation |  Landry, ML; Nilewski, C; Siu, M; Villemure, E; Wang, Y; Wei, B; Ashley, MA; Do, S; Gazzard, LJ; Green, SA AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF US Patent US20240025919 Publication Date 1/25/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas [G12D] |
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| Name: | GTPase KRas [G12D] |
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| Synonyms: | GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 21713.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01116[G12D] |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM647890 |
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| n/a |
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| Name | BDBM647890 |
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| Synonyms: | US20240025919, Compound 122 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H35F6N7O2 |
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| Mol. Mass. | 663.6564 |
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| SMILES | CC1CC[C@@]2(COc3nc4N5C[C@H]6CC[C@H](N6)[C@H]5[C@H](C)Oc5nc(c(F)c(n3)c45)-c3cc(N)c(F)c(C)c3C(F)(F)F)C[C@@H](F)CN12 |r| |
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| Structure | 
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