| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas [G12D] |
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| Ligand | BDBM647901 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | KRAS G12D LoEnz Biochemical Assay |
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| IC50 | 0.080±n/a nM |
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| Citation |  Landry, ML; Nilewski, C; Siu, M; Villemure, E; Wang, Y; Wei, B; Ashley, MA; Do, S; Gazzard, LJ; Green, SA AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF US Patent US20240025919 Publication Date 1/25/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas [G12D] |
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| Name: | GTPase KRas [G12D] |
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| Synonyms: | GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 21713.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01116[G12D] |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM647901 |
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| n/a |
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| Name | BDBM647901 |
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| Synonyms: | US20240025919, Compound 133 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H41F5N8O3 |
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| Mol. Mass. | 716.7439 |
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| SMILES | C[C@@H]1Oc2nc(c(F)c3nc(OC[C@@H]4CC[C@@H]5C[C@H](CCN45)C(=O)N(C)C)nc(N4C[C@H]5CC[C@H](N5)[C@@H]14)c23)-c1cc(N)c(F)c(C)c1C(F)(F)F |r| |
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| Structure | 
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