Ki Summary

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Target

Poly [ADP-ribose] polymerase tankyrase-2

Ligand

BDBM657074

Substrate/Competitor

n/a

Meas. Tech.

Biochemical Assay

IC50

2.00±n/a nM

Citation

Krauss, S; Nazare, M; Lehtio, L; Waaler, J; Wegert, A; Leenders, RG 1,2,4-triazole derivatives as tankyrase inhibitors US Patent US11926614 Publication Date 3/12/2024

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-2

Name:

Poly [ADP-ribose] polymerase tankyrase-2

Synonyms:

Type:

Enzyme

Mol. Mass.:

126937.16

Organism:

Homo sapiens (Human)

Description:

Q9H2K2

Residue:

1166

Sequence:

MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKST
PLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR
DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDE
LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK
DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG
ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH
PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV
KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQL
LQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS
VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA
AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR
VKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAA
SYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQT
PLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASS
LDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQIT
LDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSP
DDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEEN
HNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTG
CPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYV
IYRGEQAYPEYLITYQIMRPEGMVDG

BDBM657074

n/a

Name

BDBM657074

Synonyms:

US11926614, Example 29

Type

Small organic molecule

Emp. Form.

C24H17F2N7OS

Mol. Mass.

489.5

SMILES

Fc1cnc2c(ccnc2c1)C(=O)N[C@H]1C[C@@H](C1)c1nnc(-c2nccs2)n1-c1ccccc1F |r,wU:14.15,wD:16.20,(8.33,-2.52,;7.56,-1.18,;6.02,-1.18,;5.25,.15,;6.02,1.48,;5.25,2.82,;6.02,4.15,;7.56,4.15,;8.33,2.82,;7.56,1.48,;8.33,.15,;3.71,2.82,;2.97,4.17,;2.94,1.48,;1.4,1.48,;.34,.36,;-.78,1.41,;.27,2.53,;-2.32,1.44,;-3.23,2.69,;-4.69,2.21,;-4.69,.67,;-5.96,-.2,;-7.42,.27,;-8.33,-.97,;-7.42,-2.22,;-5.96,-1.74,;-3.23,.2,;-2.73,-1.26,;-3.73,-2.43,;-3.23,-3.88,;-1.71,-4.17,;-.71,-3,;-1.22,-1.55,;-.16,-.43,)|

Structure