| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aromatase |
|---|
| Ligand | BDBM10018 |
|---|
| Substrate/Competitor | BDBM8592 |
|---|
| Meas. Tech. | Aromatase Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 12±1.8 nM |
|---|
| Citation |  Woo, LW; Sutcliffe, OB; Bubert, C; Grasso, A; Chander, SK; Purohit, A; Reed, MJ; Potter, BV First dual aromatase-steroid sulfatase inhibitors. J Med Chem46:3193-6 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Aromatase |
|---|
| Name: | Aromatase |
|---|
| Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 57888.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11511 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
|
|
|
|---|
| BDBM10018 |
|---|
| BDBM8592 |
|---|
| Name | BDBM10018 |
|---|
| Synonyms: | (4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-2-fluorophenyl) sulfamate | JMC503540 Compound 3 | YM511-based dual aromatase-sulfatase inhibitor (DASI) 5 | dual aromatase-sulfatase inhibitor 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H13FN6O3S |
|---|
| Mol. Mass. | 388.376 |
|---|
| SMILES | NS(=O)(=O)Oc1ccc(CN(c2ccc(cc2)C#N)n2cnnc2)cc1F |
|---|
| Structure | 
|
|---|
Search and Browse
