| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM10604 |
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| Substrate/Competitor | BDBM8978 |
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| Meas. Tech. | Cholinesterase Inhibition Assay |
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| IC50 | 120±n/a nM |
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| Citation |  Luo, W; Yu, QS; Kulkarni, SS; Parrish, DA; Holloway, HW; Tweedie, D; Shafferman, A; Lahiri, DK; Brossi, A; Greig, NH Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J Med Chem49:2174-85 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
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| Type: | Homotetramer |
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| Mol. Mass.: | 68422.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06276 |
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| Residue: | 602 |
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| Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
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| BDBM10604 |
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| BDBM8978 |
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| Name | BDBM10604 |
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| Synonyms: | (+)-(5R)-5-Methyl-4,5-dihydro-2,5-methano-1,3-benzodioxepin-7-yl N-Ethylcarbamate | (1R)-1-methyl-8,10-dioxatricyclo[7.2.1.0^{2,7}]dodeca-2,4,6-trien-4-yl N-ethylcarbamate | Benzodioxepine Carbamate 11b |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17NO4 |
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| Mol. Mass. | 263.2891 |
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| SMILES | CCNC(=O)Oc1ccc2OC3C[C@@](C)(CO3)c2c1 |r| |
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| Structure | 
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