Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM314500 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Receptor Radioligand Binding Assay |
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Ki | 5.00±n/a nM |
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Citation | Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Substituted 2-azabicycles and their use as orexin receptor modulators US Patent US9611262 Publication Date 4/4/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
Type: | Protein |
Mol. Mass.: | 46817.55 |
Organism: | Rattus norvegicus (Rat) |
Description: | P56718 |
Residue: | 416 |
Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
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BDBM314500 |
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n/a |
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Name | BDBM314500 |
Synonyms: | ((1S*,3R*,4S*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-(pyrimidin-2-yl)pyridin-2-yl)methanone | US9611262, Example 62 |
Type | Small organic molecule |
Emp. Form. | C23H21F3N6O |
Mol. Mass. | 454.4476 |
SMILES | CC1C2CC(Nc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncccc1-c1ncccn1 |TLB:19:18:4.3:17,THB:5:4:18.1:17,0:1:4.3:17| |
Structure |
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