Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM314665 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Receptor Radioligand Binding Assay |
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Ki | 3.00±n/a nM |
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Citation | Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Substituted 2-azabicycles and their use as orexin receptor modulators US Patent US9611262 Publication Date 4/4/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM314665 |
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n/a |
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Name | BDBM314665 |
Synonyms: | US9611262, Example 197 | [(1R,3R,4S,6R)-3-[(5-chloro-2-pyridyl)oxy]-2,2-dideuterio-6-methyl-5-azabicyclo[2.2.1]heptan-5-yl]-[3-fluoro-2-(triazol-2-yl)phenyl]methanone |
Type | Small organic molecule |
Emp. Form. | C21H19ClFN5O2 |
Mol. Mass. | 427.859 |
SMILES | CC1C2CC(Oc3ccc(Cl)cn3)C(C2)N1C(=O)c1cccc(F)c1-n1nccn1 |TLB:16:15:4.3:14,THB:5:4:15.1:14,0:1:4.3:14| |
Structure |
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