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TargetOrexin/Hypocretin receptor type 1
LigandBDBM314665
Substrate/Competitorn/a
Meas. Tech.Receptor Radioligand Binding Assay
Ki 3.00±n/a nM
Citation Shireman, BTLebold, TPDvorak, CACoate, HRZiff, JMPreville, CGelin, CChen, G Substituted 2-azabicycles and their use as orexin receptor modulators US Patent US9611262 Publication Date 4/4/2017
More Info.:Get all data from this article,  Assay Method
 
Orexin/Hypocretin receptor type 1
Name:Orexin/Hypocretin receptor type 1
Synonyms:HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:Protein
Mol. Mass.:47554.50
Organism:Homo sapiens (Human)
Description:O43613
Residue:425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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  Blast E-value cutoff:
BDBM314665
n/a
NameBDBM314665
Synonyms:US9611262, Example 197 | [(1R,3R,4S,6R)-3-[(5-chloro-2-pyridyl)oxy]-2,2-dideuterio-6-methyl-5-azabicyclo[2.2.1]heptan-5-yl]-[3-fluoro-2-(triazol-2-yl)phenyl]methanone
TypeSmall organic molecule
Emp. Form.C21H19ClFN5O2
Mol. Mass.427.859
SMILESCC1C2CC(Oc3ccc(Cl)cn3)C(C2)N1C(=O)c1cccc(F)c1-n1nccn1 |TLB:16:15:4.3:14,THB:5:4:15.1:14,0:1:4.3:14|
Structure
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