Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM314687 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Receptor Radioligand Binding Assay |
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Ki | 1014±n/a nM |
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Citation | Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Substituted 2-azabicycles and their use as orexin receptor modulators US Patent US9611262 Publication Date 4/4/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM314687 |
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n/a |
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Name | BDBM314687 |
Synonyms: | (2-(pyrimidin-2-yl)phenyl)((1S,3R,4R,6R)-3-methyl-6-((6-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone | US9611262, Example 219 |
Type | Small organic molecule |
Emp. Form. | C24H20F4N4O2 |
Mol. Mass. | 472.4348 |
SMILES | CC1C2CC(Oc3ccc(c(F)n3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncccn1 |TLB:20:19:4.3:18,THB:5:4:19.1:18,0:1:4.3:18| |
Structure |
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