| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM10963 |
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| Substrate/Competitor | BDBM8978 |
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| Meas. Tech. | Cholinesterase Inhibition Assay |
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| IC50 | 660±n/a nM |
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| Citation |  Yu, QS; Zhu, X; Holloway, HW; Whittaker, NF; Brossi, A; Greig, NH Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. J Med Chem45:3684-91 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
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| Type: | Homotetramer |
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| Mol. Mass.: | 68422.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06276 |
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| Residue: | 602 |
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| Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
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| BDBM10963 |
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| BDBM8978 |
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| Name | BDBM10963 |
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| Synonyms: | (1R,3aS,8aS)-1-hydroxy-1,3a,8-trimethyl-5-[(methylcarbamoyl)oxy]-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-1-ium chloride | Geneserine N-oxide | geneserine.HCl |
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| Type | Small organic molecule |
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| Emp. Form. | C15H22N3O3 |
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| Mol. Mass. | 292.3529 |
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| SMILES | [H][C@@]12N(C)c3ccc(OC(=O)NC)cc3[C@]1(C)CC[N@@+]2(C)O |r| |
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| Structure | 
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