| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-type tyrosine-protein kinase FLT3 [D835Y] |
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| Ligand | BDBM319752 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FLT3 Kinase assay |
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| Kd | 46±0.0 nM |
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| Citation |  Czardybon, W; Brzózka, K; Galezowski, M; Windak, R; Milik, M; Zawadzka, M; Guzik, P; Wincza, E; Prokop, M; Wiklik, K; Sabiniarz, A; Cholody, WM; Horvath, R; Rzymski, T Benzimidazole derivatives as kinase inhibitors US Patent US10174013 Publication Date 1/8/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-type tyrosine-protein kinase FLT3 [D835Y] |
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| Name: | Receptor-type tyrosine-protein kinase FLT3 [D835Y] |
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| Synonyms: | CD135 | FL cytokine receptor | FLK2 | FLT3 | FLT3(D835Y) | FLT3_HUMAN | Receptor-type tyrosine-protein kinase FLT3 (D835Y) | STK-1 | STK1 | Stem cell tyrosine kinase 1 | Tyrosine Kinase FLT3 Mutant (D835Y) |
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| Type: | n/a |
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| Mol. Mass.: | 112937.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36888 D835Y |
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| Residue: | 993 |
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| Sequence: | MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP
EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL
QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD
ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE
CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM
STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE
IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA
ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE
GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD
NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD
LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS
ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE
HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL
NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARYIMSDS
NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK
LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
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| BDBM319752 |
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| n/a |
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| Name | BDBM319752 |
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| Synonyms: | US10174013, Example 1A | US10174013, Example 1X | US10174013, Example 1Y |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15Br2N5O2 |
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| Mol. Mass. | 433.099 |
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| SMILES | CCn1c(nc2c(c(Br)c(Br)cc12)[N+]([O-])=O)N1CCNCC1 |
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| Structure | 
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