| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM323717 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HDAC Inhibition Assay |
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| IC50 | 0.780±n/a nM |
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| Citation |  Hooker, JM; Wang, C; Schroeder, FA Imaging histone deacetylases with a radiotracer using positron emission tomography US Patent US10188756 Publication Date 1/29/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM323717 |
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| n/a |
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| Name | BDBM323717 |
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| Synonyms: | US10188756, Compound CN148 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27FN2O2 |
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| Mol. Mass. | 358.4497 |
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| SMILES | ONC(=O)\C=C\c1ccc(CNCC23CC4CC(CC(C4)C2)C3)c(F)c1 |TLB:16:17:21:15.20.14,20:15:22:21.19.18,20:19:22:15.16.14,THB:16:15:21:22.17.18| |
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| Structure | 
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