Ki Summary

Reaction Details

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Target

E3 ubiquitin-protein ligase Mdm2 [17-125]

Ligand

BDBM326332

Substrate/Competitor

n/a

Meas. Tech.

FRET Assay

IC50

4.50±n/a nM

Citation

Dinsmore, C; Fradera Llinas, FX; Kudale, AA; Machacek, M; Reutershan, MH; Thompson, CF; Trotter, BW; Yang, L; Altman, MD; Bogen, SL; Doll, RJ; Voss, ME Substituted pyrrolopyrimidines as HDM2 inhibitors US Patent US9637493 Publication Date 5/2/2017

More Info.:

Get all data from this article, Assay Method

E3 ubiquitin-protein ligase Mdm2 [17-125]

Name:

E3 ubiquitin-protein ligase Mdm2 [17-125]

Synonyms:

Double minute 2 protein | E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN | p53-binding protein Mdm2

Type:

Enzyme Catalytic Domain

Mol. Mass.:

12522.24

Organism:

Homo sapiens (Human)

Description:

Residue 17 to 125

Residue:

109

Sequence:

SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVY
CSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSEN

BDBM326332

n/a

Name

BDBM326332

Synonyms:

3-{4-(5-chloropyridin-3- yl)-6-[(1R or S)-1-fluoro- 1-(3-fluoropyridin-2- yl)ethyl]-5-[(trans-4- methylcyclohexyl)methyl]- 5H-pyrrolo[3,2- d]pyrimidin-2-yl}-1,2,4- oxadiazol-5(4H)-one (Enantiomer 1) | US9637493, 8.5 | US9637493, 8.6

Type

Small organic molecule

Emp. Form.

C28H26ClF2N7O2

Mol. Mass.

566.002

SMILES

C[C@H]1CC[C@H](Cn2c(cc3nc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)C(C)(F)c2ncccc2F)CC1 |r,wU:4.4,wD:1.0,(6.49,-5.23,;5.16,-4.46,;5.16,-2.92,;3.82,-2.15,;2.49,-2.92,;1.16,-2.15,;1.16,-.61,;2.06,.64,;1.16,1.88,;-.31,1.41,;-1.64,2.18,;-2.98,1.41,;-2.98,-.13,;-1.64,-.9,;-1.64,-2.44,;-.31,-3.21,;-.31,-4.75,;-1.64,-5.52,;-2.98,-4.75,;-4.31,-5.52,;-2.98,-3.21,;-.31,-.13,;-4.31,2.18,;-5.78,1.7,;-6.68,2.95,;-5.78,4.19,;-6.55,5.52,;-4.31,3.72,;3.6,.64,;4.93,-.13,;3.6,-.9,;4.37,1.97,;5.91,1.97,;6.68,3.3,;5.91,4.64,;4.37,4.64,;3.6,3.3,;2.06,3.3,;2.49,-4.46,;3.82,-5.23,)|

Structure