Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM163989 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Rat and Human Orexin 1 Receptor Radioligand Binding Assay |
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Ki | 15.0±n/a nM |
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Citation | Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Substituted 7-azabicycles and their use as orexin receptor modulators US Patent US9637496 Publication Date 5/2/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
Type: | Protein |
Mol. Mass.: | 46817.55 |
Organism: | Rattus norvegicus (Rat) |
Description: | P56718 |
Residue: | 416 |
Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
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BDBM163989 |
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n/a |
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Name | BDBM163989 |
Synonyms: | US9062078, 120 | US9475819, 120 | US9637496, 120 | US9695183, 120 |
Type | Small organic molecule |
Emp. Form. | C21H19ClFN5O2 |
Mol. Mass. | 427.859 |
SMILES | Fc1ccc(OCC2CC3CCC2N3C(=O)c2cc(Cl)ccc2-n2nccn2)nc1 |THB:6:7:11.10:13| |
Structure |
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