| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Ligand | BDBM332148 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | cAMP HTRF Assay to Determine the Activity of hPDE4B1 |
|---|
| IC50 | <100±n/a nM |
|---|
| Citation |  Nardi, A; Jakob, F; Konetzki, I; Craan, T; Hesslinger, C; Doodeman, R Substituted pyrimidine compounds US Patent US10189854 Publication Date 1/29/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 83318.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q07343 |
|---|
| Residue: | 736 |
|---|
| Sequence: | MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
|
|
|
|---|
| BDBM332148 |
|---|
| n/a |
|---|
| Name | BDBM332148 |
|---|
| Synonyms: | US10189854, Compound 104 | [(2R,6S)-2,6-dimethyl-morpholin-4-yl]-[1-[5-(2-fluorophenyl)-pyrimidin-2-yl]-spiro[1,2-dihydro-indole-3,1'-cyclopropane]-6-yl]-methanone |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H27FN4O2 |
|---|
| Mol. Mass. | 458.5273 |
|---|
| SMILES | C[C@H]1CN(C[C@@H](C)O1)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F |
|---|
| Structure | 
|
|---|
Search and Browse
