Compile Data Set for Download or QSAR

Found 446 hits with Last Name = 'hesslinger' and Initial = 'c'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50386178 (CHEMBL1800346 | ONO-1714) Show SMILES C[C@H]1CC(N)=N[C@@H]2[C@H](Cl)[C@H]12 |r,c:4| Show InChI InChI=1S/C7H11ClN2/c1-3-2-4(9)10-7-5(3)6(7)8/h3,5-7H,2H2,1H3,(H2,9,10)/t3-,5?,6+,7-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.86	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nycomed GmbH Curated by ChEMBL					Assay Description Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting				Bioorg Med Chem Lett 21: 4228-32 (2011) Article DOI: 10.1016/j.bmcl.2011.05.073 BindingDB Entry DOI: 10.7270/Q2H996GJ
					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Homo sapiens (Human))	BDBM50386178 (CHEMBL1800346 | ONO-1714) Show SMILES C[C@H]1CC(N)=N[C@@H]2[C@H](Cl)[C@H]12 |r,c:4| Show InChI InChI=1S/C7H11ClN2/c1-3-2-4(9)10-7-5(3)6(7)8/h3,5-7H,2H2,1H3,(H2,9,10)/t3-,5?,6+,7-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nycomed GmbH Curated by ChEMBL					Assay Description Inhibition of human eNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting				Bioorg Med Chem Lett 21: 4228-32 (2011) Article DOI: 10.1016/j.bmcl.2011.05.073 BindingDB Entry DOI: 10.7270/Q2H996GJ
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50124535 (1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...) Show SMILES NC1=NC2(CCN(CC2)C(=O)c2ccc(nc2)C#N)Nc2c(F)ccc(F)c12 |t:1| Show InChI InChI=1S/C19H16F2N6O/c20-13-3-4-14(21)16-15(13)17(23)26-19(25-16)5-7-27(8-6-19)18(28)11-1-2-12(9-22)24-10-11/h1-4,10,25H,5-8H2,(H2,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	37.1	n/a	n/a	n/a	n/a	n/a	n/a
Nycomed GmbH Curated by ChEMBL					Assay Description Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting				Bioorg Med Chem Lett 21: 4228-32 (2011) Article DOI: 10.1016/j.bmcl.2011.05.073 BindingDB Entry DOI: 10.7270/Q2H996GJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50418856 (CHEMBL1800534) Show SMILES COc1ccnc(CCc2nc3ncc(cc3[nH]2)-c2ccccc2)c1 Show InChI InChI=1S/C20H18N4O/c1-25-17-9-10-21-16(12-17)7-8-19-23-18-11-15(13-22-20(18)24-19)14-5-3-2-4-6-14/h2-6,9-13H,7-8H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38.9	n/a	n/a	n/a	n/a	n/a	n/a
Nycomed GmbH Curated by ChEMBL					Assay Description Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting				Bioorg Med Chem Lett 21: 4228-32 (2011) Article DOI: 10.1016/j.bmcl.2011.05.073 BindingDB Entry DOI: 10.7270/Q2H996GJ
					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Homo sapiens (Human))	BDBM50091805 (2-amino-4,6-dimethylpyridine | 4,6-Dimethyl-pyridi...) Show SMILES Cc1cc(C)nc(N)c1 Show InChI InChI=1S/C7H10N2/c1-5-3-6(2)9-7(8)4-5/h3-4H,1-2H3,(H2,8,9)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	44.7	n/a	n/a	n/a	n/a	n/a	n/a
Nycomed GmbH Curated by ChEMBL					Assay Description Inhibition of human eNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting				Bioorg Med Chem Lett 21: 4228-32 (2011) Article DOI: 10.1016/j.bmcl.2011.05.073 BindingDB Entry DOI: 10.7270/Q2H996GJ
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50418855 (CHEMBL1800533) Show SMILES CCCCc1cnc2nc(CCc3cc(OC)ccn3)[nH]c2c1 Show InChI InChI=1S/C18H22N4O/c1-3-4-5-13-10-16-18(20-12-13)22-17(21-16)7-6-14-11-15(23-2)8-9-19-14/h8-12H,3-7H2,1-2H3,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55.0	n/a	n/a	n/a	n/a	n/a	n/a
Nycomed GmbH Curated by ChEMBL					Assay Description Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting				Bioorg Med Chem Lett 21: 4228-32 (2011) Article DOI: 10.1016/j.bmcl.2011.05.073 BindingDB Entry DOI: 10.7270/Q2H996GJ
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50418844 (CHEMBL1800347) Show SMILES COc1ccnc(NC2CCN(CC2)C(=O)c2ccc(nc2)C#N)c1 Show InChI InChI=1S/C18H19N5O2/c1-25-16-4-7-20-17(10-16)22-14-5-8-23(9-6-14)18(24)13-2-3-15(11-19)21-12-13/h2-4,7,10,12,14H,5-6,8-9H2,1H3,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	70.8	n/a	n/a	n/a	n/a	n/a	n/a
Nycomed GmbH Curated by ChEMBL					Assay Description Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting				Bioorg Med Chem Lett 21: 4228-32 (2011) Article DOI: 10.1016/j.bmcl.2011.05.073 BindingDB Entry DOI: 10.7270/Q2H996GJ
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50418849 (CHEMBL1738840) Show SMILES COc1ccnc(CCc2nc3ncccc3[nH]2)c1 Show InChI InChI=1S/C14H14N4O/c1-19-11-6-8-15-10(9-11)4-5-13-17-12-3-2-7-16-14(12)18-13/h2-3,6-9H,4-5H2,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	81.3	n/a	n/a	n/a	n/a	n/a	n/a
Nycomed GmbH Curated by ChEMBL					Assay Description Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting				Bioorg Med Chem Lett 21: 4228-32 (2011) Article DOI: 10.1016/j.bmcl.2011.05.073 BindingDB Entry DOI: 10.7270/Q2H996GJ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332053 (US10189854, Compound 1 | [1-[5-(2-Fluorophenyl)-py...) Show SMILES Fc1ccccc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C25H23FN4O2/c26-21-4-2-1-3-19(21)18-14-27-24(28-15-18)30-16-25(7-8-25)20-6-5-17(13-22(20)30)23(31)29-9-11-32-12-10-29/h1-6,13-15H,7-12,16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332054 (1-[5-(2-Fluorophenyl)-pyrimidin-2-yl]-N,N-dimethyl...) Show SMILES CN(C)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F Show InChI InChI=1S/C23H21FN4O/c1-27(2)21(29)15-7-8-18-20(11-15)28(14-23(18)9-10-23)22-25-12-16(13-26-22)17-5-3-4-6-19(17)24/h3-8,11-13H,9-10,14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332055 (US10189854, Compound 3 | [1-[5-(1-Fluorophenyl)-py...) Show SMILES Fc1ccccc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCCC1 Show InChI InChI=1S/C25H23FN4O/c26-21-6-2-1-5-19(21)18-14-27-24(28-15-18)30-16-25(9-10-25)20-8-7-17(13-22(20)30)23(31)29-11-3-4-12-29/h1-2,5-8,13-15H,3-4,9-12,16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332056 (4-[1-[5-(2-Fluorophenyl)-pyrimidin-2-yl]-spiro[1,2...) Show SMILES Fc1ccccc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCNC(=O)C1 Show InChI InChI=1S/C25H22FN5O2/c26-20-4-2-1-3-18(20)17-12-28-24(29-13-17)31-15-25(7-8-25)19-6-5-16(11-21(19)31)23(33)30-10-9-27-22(32)14-30/h1-6,11-13H,7-10,14-15H2,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332057 (US10189854, Compound 5 | [1-[5-(2-Fluorophenyl)-py...) Show SMILES Fc1ccccc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCNCC1 Show InChI InChI=1S/C25H24FN5O/c26-21-4-2-1-3-19(21)18-14-28-24(29-15-18)31-16-25(7-8-25)20-6-5-17(13-22(20)31)23(32)30-11-9-27-10-12-30/h1-6,13-15,27H,7-12,16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332059 (Morpholin-4-yl-[1-(5-phenyl-pyrimidin-2-yl)-spiro[...) Show SMILES O=C(N1CCOCC1)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1 Show InChI InChI=1S/C25H24N4O2/c30-23(28-10-12-31-13-11-28)19-6-7-21-22(14-19)29(17-25(21)8-9-25)24-26-15-20(16-27-24)18-4-2-1-3-5-18/h1-7,14-16H,8-13,17H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332060 (US10189854, Compound 8 | [1-[5-(2,4-Difluoro-pheny...) Show SMILES Fc1ccc(c(F)c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C25H22F2N4O2/c26-18-2-3-19(21(27)12-18)17-13-28-24(29-14-17)31-15-25(5-6-25)20-4-1-16(11-22(20)31)23(32)30-7-9-33-10-8-30/h1-4,11-14H,5-10,15H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332062 (Morpholin-4-yl-[1-(5-o-tolyl-pyrimidin-2-yl)-spiro...) Show SMILES Cc1ccccc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H26N4O2/c1-18-4-2-3-5-21(18)20-15-27-25(28-16-20)30-17-26(8-9-26)22-7-6-19(14-23(22)30)24(31)29-10-12-32-13-11-29/h2-7,14-16H,8-13,17H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332063 (US10189854, Compound 15 | [1-[5-(2,3-Difluoro-phen...) Show SMILES Fc1cccc(c1F)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C25H22F2N4O2/c26-20-3-1-2-18(22(20)27)17-13-28-24(29-14-17)31-15-25(6-7-25)19-5-4-16(12-21(19)31)23(32)30-8-10-33-11-9-30/h1-5,12-14H,6-11,15H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332064 (US10189854, Compound 16 | [1-[5-(2-Fluoro-5-methox...) Show SMILES COc1ccc(F)c(c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H25FN4O3/c1-33-19-3-5-22(27)20(13-19)18-14-28-25(29-15-18)31-16-26(6-7-26)21-4-2-17(12-23(21)31)24(32)30-8-10-34-11-9-30/h2-5,12-15H,6-11,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332065 (US10189854, Compound 17 | [1-[5-(2-Fluoro-4-methox...) Show SMILES COc1ccc(c(F)c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H25FN4O3/c1-33-19-3-4-20(22(27)13-19)18-14-28-25(29-15-18)31-16-26(6-7-26)21-5-2-17(12-23(21)31)24(32)30-8-10-34-11-9-30/h2-5,12-15H,6-11,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332070 (4-Fluoro-3-[2-[6-(morpholine-4-carbonyl)-spiro[1,2...) Show SMILES Fc1ccc(cc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1)C#N Show InChI InChI=1S/C26H22FN5O2/c27-22-4-1-17(13-28)11-20(22)19-14-29-25(30-15-19)32-16-26(5-6-26)21-3-2-18(12-23(21)32)24(33)31-7-9-34-10-8-31/h1-4,11-12,14-15H,5-10,16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332071 (US10189854, Compound 23 | [1-[5-[2-Fluoro-5-(trifl...) Show SMILES Fc1ccc(cc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1)C(F)(F)F Show InChI InChI=1S/C26H22F4N4O2/c27-21-4-2-18(26(28,29)30)12-19(21)17-13-31-24(32-14-17)34-15-25(5-6-25)20-3-1-16(11-22(20)34)23(35)33-7-9-36-10-8-33/h1-4,11-14H,5-10,15H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332074 (3-Fluoro-4-[2-[6-(morpholine-4-carbonyl)-spiro[1,2...) Show SMILES NC(=O)c1ccc(c(F)c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H24FN5O3/c27-21-11-16(23(28)33)1-3-19(21)18-13-29-25(30-14-18)32-15-26(5-6-26)20-4-2-17(12-22(20)32)24(34)31-7-9-35-10-8-31/h1-4,11-14H,5-10,15H2,(H2,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332075 (US10189854, Compound 27 | [1-[5-(2,6-Difluoro-phen...) Show SMILES Fc1cccc(F)c1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C25H22F2N4O2/c26-19-2-1-3-20(27)22(19)17-13-28-24(29-14-17)31-15-25(6-7-25)18-5-4-16(12-21(18)31)23(32)30-8-10-33-11-9-30/h1-5,12-14H,6-11,15H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332077 (US10189854, Compound 29 | [1-[5-(2-Fluoro-4-methyl...) Show SMILES CS(=O)(=O)c1ccc(c(F)c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H25FN4O4S/c1-36(33,34)19-3-4-20(22(27)13-19)18-14-28-25(29-15-18)31-16-26(6-7-26)21-5-2-17(12-23(21)31)24(32)30-8-10-35-11-9-30/h2-5,12-15H,6-11,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332079 (US10189854, Compound 31 | [1-[5-(2-Methoxyphenyl)-...) Show SMILES COc1ccccc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H26N4O3/c1-32-23-5-3-2-4-20(23)19-15-27-25(28-16-19)30-17-26(8-9-26)21-7-6-18(14-22(21)30)24(31)29-10-12-33-13-11-29/h2-7,14-16H,8-13,17H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332081 (US10189854, Compound 34 | US10189854, Compound 94 ...) Show SMILES OCCN1CCN(CC1)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F Show InChI InChI=1S/C27H28FN5O2/c28-23-4-2-1-3-21(23)20-16-29-26(30-17-20)33-18-27(7-8-27)22-6-5-19(15-24(22)33)25(35)32-11-9-31(10-12-32)13-14-34/h1-6,15-17,34H,7-14,18H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332082 (4-Fluoro-3-[2-[6-(morpholine-4-carbonyl)-spiro[1,2...) Show SMILES NC(=O)c1ccc(F)c(c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H24FN5O3/c27-21-4-2-16(23(28)33)11-19(21)18-13-29-25(30-14-18)32-15-26(5-6-26)20-3-1-17(12-22(20)32)24(34)31-7-9-35-10-8-31/h1-4,11-14H,5-10,15H2,(H2,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332084 (4-[1-[5-(2-Fluorophenyl)-pyrimidin-2-yl]spiro[1,2-...) Show SMILES CN1CCN(CC1=O)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F Show InChI InChI=1S/C26H24FN5O2/c1-30-10-11-31(15-23(30)33)24(34)17-6-7-20-22(12-17)32(16-26(20)8-9-26)25-28-13-18(14-29-25)19-4-2-3-5-21(19)27/h2-7,12-14H,8-11,15-16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332086 (US10189854, Compound 40 | [(3R)-3-Amino-pyrrolidin...) Show SMILES N[C@@H]1CCN(C1)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F Show InChI InChI=1S/C25H24FN5O/c26-21-4-2-1-3-19(21)17-12-28-24(29-13-17)31-15-25(8-9-25)20-6-5-16(11-22(20)31)23(32)30-10-7-18(27)14-30/h1-6,11-13,18H,7-10,14-15,27H2/t18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332087 (N-(2-Amino-ethyl)-1-[5-(2-fluorophenyl)-pyrimidin-...) Show SMILES CN(CCN)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F Show InChI InChI=1S/C24H24FN5O/c1-29(11-10-26)22(31)16-6-7-19-21(12-16)30(15-24(19)8-9-24)23-27-13-17(14-28-23)18-4-2-3-5-20(18)25/h2-7,12-14H,8-11,15,26H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332088 (US10189854, Compound 42 | [1-[5-(2-Fluoro-5-methyl...) Show SMILES CS(=O)(=O)c1ccc(F)c(c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H25FN4O4S/c1-36(33,34)19-3-5-22(27)20(13-19)18-14-28-25(29-15-18)31-16-26(6-7-26)21-4-2-17(12-23(21)31)24(32)30-8-10-35-11-9-30/h2-5,12-15H,6-11,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332089 (US10189854, Compound 43 | [1-[5-(4-Fluorophenyl)-p...) Show SMILES Fc1ccc(cc1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C25H23FN4O2/c26-20-4-1-17(2-5-20)19-14-27-24(28-15-19)30-16-25(7-8-25)21-6-3-18(13-22(21)30)23(31)29-9-11-32-12-10-29/h1-6,13-15H,7-12,16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332090 (US10189854, Compound 44 | [1-[5-(2-Fluorophenyl)-p...) Show SMILES O[C@@H]1CCN(C1)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F Show InChI InChI=1S/C25H23FN4O2/c26-21-4-2-1-3-19(21)17-12-27-24(28-13-17)30-15-25(8-9-25)20-6-5-16(11-22(20)30)23(32)29-10-7-18(31)14-29/h1-6,11-13,18,31H,7-10,14-15H2/t18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332094 (US10189854, Compound 48 | [1-[5-(3-Methoxyphenyl)-...) Show SMILES COc1cccc(c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H26N4O3/c1-32-21-4-2-3-18(13-21)20-15-27-25(28-16-20)30-17-26(7-8-26)22-6-5-19(14-23(22)30)24(31)29-9-11-33-12-10-29/h2-6,13-16H,7-12,17H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332095 (US10189854, Compound 49 | [1-(5-Phenyl-pyrimidin-2...) Show SMILES O=C(N1CCNCC1)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1 Show InChI InChI=1S/C25H25N5O/c31-23(29-12-10-26-11-13-29)19-6-7-21-22(14-19)30(17-25(21)8-9-25)24-27-15-20(16-28-24)18-4-2-1-3-5-18/h1-7,14-16,26H,8-13,17H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332096 (US10189854, Compound 50 | [1-[5-(3,5-Difluoro-phen...) Show SMILES Fc1cc(F)cc(c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C25H22F2N4O2/c26-19-9-17(10-20(27)12-19)18-13-28-24(29-14-18)31-15-25(3-4-25)21-2-1-16(11-22(21)31)23(32)30-5-7-33-8-6-30/h1-2,9-14H,3-8,15H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332098 (US10189854, Compound 52 | [1-[5-(2-Fluoro-5-methyl...) Show SMILES Cc1ccc(F)c(c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H25FN4O2/c1-17-2-5-22(27)20(12-17)19-14-28-25(29-15-19)31-16-26(6-7-26)21-4-3-18(13-23(21)31)24(32)30-8-10-33-11-9-30/h2-5,12-15H,6-11,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332100 (3-[2-[6-(Morpholine-4-carbonyl)-spiro[1,2-dihydro-...) Show SMILES NC(=O)c1cccc(c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H25N5O3/c27-23(32)18-3-1-2-17(12-18)20-14-28-25(29-15-20)31-16-26(6-7-26)21-5-4-19(13-22(21)31)24(33)30-8-10-34-11-9-30/h1-5,12-15H,6-11,16H2,(H2,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332101 (4-[1-(5-Phenyl-pyrimidin-2-yl)-spiro[1,2-dihydro-i...) Show SMILES O=C(N1CCNC(=O)C1)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1 Show InChI InChI=1S/C25H23N5O2/c31-22-15-29(11-10-26-22)23(32)18-6-7-20-21(12-18)30(16-25(20)8-9-25)24-27-13-19(14-28-24)17-4-2-1-3-5-17/h1-7,12-14H,8-11,15-16H2,(H,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332102 (3-[2-[6-(Morpholine-4-carbonyl)-spiro[1,2-dihydro-...) Show SMILES O=C(N1CCOCC1)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1cccc(c1)C#N Show InChI InChI=1S/C26H23N5O2/c27-14-18-2-1-3-19(12-18)21-15-28-25(29-16-21)31-17-26(6-7-26)22-5-4-20(13-23(22)31)24(32)30-8-10-33-11-9-30/h1-5,12-13,15-16H,6-11,17H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332103 (US10189854, Compound 57 | [1-[5-(3-Fluorophenyl)-p...) Show SMILES Fc1cccc(c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C25H23FN4O2/c26-20-3-1-2-17(12-20)19-14-27-24(28-15-19)30-16-25(6-7-25)21-5-4-18(13-22(21)30)23(31)29-8-10-32-11-9-29/h1-5,12-15H,6-11,16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332104 (US10189854, Compound 58 | [1-[5-(5-Chloro-2-fluoro...) Show SMILES Fc1ccc(Cl)cc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C25H22ClFN4O2/c26-18-2-4-21(27)19(12-18)17-13-28-24(29-14-17)31-15-25(5-6-25)20-3-1-16(11-22(20)31)23(32)30-7-9-33-10-8-30/h1-4,11-14H,5-10,15H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332105 (US10189854, Compound 59 | [1-(5-Phenyl-pyrimidin-2...) Show SMILES O=C(N1CCCC1)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1 Show InChI InChI=1S/C25H24N4O/c30-23(28-12-4-5-13-28)19-8-9-21-22(14-19)29(17-25(21)10-11-25)24-26-15-20(16-27-24)18-6-2-1-3-7-18/h1-3,6-9,14-16H,4-5,10-13,17H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332106 (US10189854, Compound 60 | [1-[5-(2-Fluorophenyl)-p...) Show SMILES CN1CCN(CC1)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F Show InChI InChI=1S/C26H26FN5O/c1-30-10-12-31(13-11-30)24(33)18-6-7-21-23(14-18)32(17-26(21)8-9-26)25-28-15-19(16-29-25)20-4-2-3-5-22(20)27/h2-7,14-16H,8-13,17H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332109 (4-[2-[6-(Morpholine-4-carbonyl)-spiro[1,2-dihydro-...) Show SMILES NC(=O)c1ccc(cc1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H25N5O3/c27-23(32)18-3-1-17(2-4-18)20-14-28-25(29-15-20)31-16-26(7-8-26)21-6-5-19(13-22(21)31)24(33)30-9-11-34-12-10-30/h1-6,13-15H,7-12,16H2,(H2,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332111 (3-Fluoro-N,N-dimethyl-4-[2-[6-(morpholine-4-carbon...) Show SMILES CN(C)C(=O)c1ccc(c(F)c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C28H28FN5O3/c1-32(2)25(35)18-3-5-21(23(29)13-18)20-15-30-27(31-16-20)34-17-28(7-8-28)22-6-4-19(14-24(22)34)26(36)33-9-11-37-12-10-33/h3-6,13-16H,7-12,17H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332118 (US10189854, Compound 72 | [1-[5-[2-Fluoro-5-(trifl...) Show SMILES Fc1ccc(OC(F)(F)F)cc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCNCC1 Show InChI InChI=1S/C26H23F4N5O2/c27-21-4-2-18(37-26(28,29)30)12-19(21)17-13-32-24(33-14-17)35-15-25(5-6-25)20-3-1-16(11-22(20)35)23(36)34-9-7-31-8-10-34/h1-4,11-14,31H,5-10,15H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332119 (US10189854, Compound 73 | [1-[5-(2-Fluoro-5-methox...) Show SMILES COc1ccc(F)c(c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCNCC1 Show InChI InChI=1S/C26H26FN5O2/c1-34-19-3-5-22(27)20(13-19)18-14-29-25(30-15-18)32-16-26(6-7-26)21-4-2-17(12-23(21)32)24(33)31-10-8-28-9-11-31/h2-5,12-15,28H,6-11,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332128 (US10189854, Compound 84 | [1-[5-(2-Fluorophenyl)-p...) Show SMILES Fc1ccccc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCCCC1 Show InChI InChI=1S/C26H25FN4O/c27-22-7-3-2-6-20(22)19-15-28-25(29-16-19)31-17-26(10-11-26)21-9-8-18(14-23(21)31)24(32)30-12-4-1-5-13-30/h2-3,6-9,14-16H,1,4-5,10-13,17H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332129 (1-[5-[1-[5-(2-Fluorophenyl)-pyrimidin-2-yl]-spiro[...) Show SMILES CC(=O)N1CCNC(C1)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F Show InChI InChI=1S/C27H26FN5O2/c1-17(34)32-11-10-29-23(15-32)25(35)18-6-7-21-24(12-18)33(16-27(21)8-9-27)26-30-13-19(14-31-26)20-4-2-3-5-22(20)28/h2-7,12-14,23,29H,8-11,15-16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair

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