Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM12532 |
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Substrate/Competitor | BDBM12500 |
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Meas. Tech. | Factor Xa Inhibition Assay |
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Ki | 2±n/a nM |
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Citation | Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs. Bioorg Med Chem Lett16:5953-7 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM12532 |
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BDBM12500 |
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Name | BDBM12532 |
Synonyms: | (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-[2-(piperidin-1-yl)ethyl]-N-(propan-2-yl)propanamide | P4 alanylamide pyrrolidin-2-one 43 |
Type | Small organic molecule |
Emp. Form. | C27H37ClN4O4S |
Mol. Mass. | 549.125 |
SMILES | CC(C)N(CCN1CCCCC1)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O |r| |
Structure |
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