| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease 1 |
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| Ligand | BDBM13297 |
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| Substrate/Competitor | BDBM12500 |
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| Meas. Tech. | Enzyme Assay and Determination of the Inhibition Constants. |
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| Ki | 2100±n/a nM |
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| Citation |  Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Sulfonamidopyrrolidinone factor Xa inhibitors: potency and selectivity enhancements via P-1 and P-4 optimization. J Med Chem42:3572-87 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Serine protease 1 |
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| Name: | Serine protease 1 |
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| Synonyms: | Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I |
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| Type: | Enzyme |
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| Mol. Mass.: | 25790.52 |
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| Organism: | Bos taurus (bovine) |
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| Description: | P00760 |
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| Residue: | 246 |
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| Sequence: | MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVS
AAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLN
SRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQIT
SNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIK
QTIASN
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| BDBM13297 |
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| BDBM12500 |
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| Name | BDBM13297 |
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| Synonyms: | 3-{[(3S)-2-oxo-3-{[5-(pyridin-2-yl)thiophene-2-]sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide | 5-Pyrid-2-ylthiophene-2-sulfonic Acid {1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide | Sulfonamidopyrrolidinone 3j |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N5O3S2 |
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| Mol. Mass. | 455.553 |
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| SMILES | NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(s3)-c3ccccn3)C2=O)c1 |r| |
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| Structure | 
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