| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform Beta of cGMP-dependent protein kinase 1 [1-351,G306E] |
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| Ligand | BDBM65501 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Microfluidic Mobility-Shift Assay |
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| pH | 7±n/a |
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| EC50 | 4.2±0.1 nM |
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| Comments | extracted |
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| Citation |  Campbell, JC; Henning, P; Franz, E; Sankaran, B; Herberg, FW; Kim, C Structural Basis of Analog Specificity in PKG I and II. ACS Chem Biol12:2388-2398 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform Beta of cGMP-dependent protein kinase 1 [1-351,G306E] |
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| Name: | Isoform Beta of cGMP-dependent protein kinase 1 [1-351,G306E] |
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| Synonyms: | KGP1_HUMAN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | cGMP-dependent protein kinase 1 [1-351,G306E] | hPKG 1 beta (aa 1-351) (G306E) |
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| Type: | Protein |
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| Mol. Mass.: | 39744.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13976-2 (1-351) (G306E) |
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| Residue: | 351 |
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| Sequence: | MGTLRDLQYALQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQA
QKQSASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMK
NLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKV
FGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSL
PEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLG
KGDWFEEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAY
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| BDBM65501 |
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| n/a |
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| Name | BDBM65501 |
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| Synonyms: | 8-pCP-cGMP | Cyclic GMP analogs | cGMP |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15ClN5O7PS |
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| Mol. Mass. | 487.811 |
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| SMILES | Nc1nc(=O)c2nc(Sc3ccc(Cl)cc3)n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c2[nH]1 |
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| Structure | 
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