| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
|---|
| Ligand | BDBM340096 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Lck Enzyme Activity |
|---|
| EC50 | >1000±n/a nM |
|---|
| Citation |  Barf, TA; Jans, CG; de Man, AP; Oubrie, AA; Raaijmakers, HC; Rewinkel, JB; Sterrenburg, JG; Wijkmans, JC 4-imidazopyridazin-1-yl-benzamides as Btk inhibitors US Patent US9758524 Publication Date 9/12/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Lck |
|---|
| Name: | Tyrosine-protein kinase Lck |
|---|
| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 57987.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06239 |
|---|
| Residue: | 509 |
|---|
| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
|
|
|
|---|
| BDBM340096 |
|---|
| n/a |
|---|
| Name | BDBM340096 |
|---|
| Synonyms: | (E)-4-(8-amino-3-((4-(dimethyl amino)but-2-enamido)methyl) imidazo[1,5-a]pyrazin-1-yl)-N- (pyridin-2-yl)benzamide | US10239883, Example 69 | US10934296, Example 69 | US9758524, Example 69 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H26N8O2 |
|---|
| Mol. Mass. | 470.5263 |
|---|
| SMILES | CN(C)C\C=C\C(=O)NCc1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 |
|---|
| Structure | 
|
|---|
Search and Browse
