Reaction Details |
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Target | Beta-secretase 1 |
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Ligand | BDBM342423 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Cell-Free Assay |
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IC50 | 146±n/a nM |
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Citation | Brodney, MA; Butler, CR; Zhang, L; O Neill, BT N-(2-(2-amino-6-substituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]OXAZIN-8a(8H)-yl)-thiazol-4-yl) amides US Patent US9771379 Publication Date 9/26/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Beta-secretase 1 |
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Name: | Beta-secretase 1 |
Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
Type: | Protein |
Mol. Mass.: | 55755.10 |
Organism: | Homo sapiens (Human) |
Description: | P56817 |
Residue: | 501 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
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BDBM342423 |
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n/a |
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Name | BDBM342423 |
Synonyms: | N-(2-((5aR,7S,9aR)-2-amino-7-methyl-5,5a,6,7-tetrahydro-4H-pyrano[3,4-d][1,3]oxazepin-9a(9H)-yl)thiazol-4-yl)-5-(difluoromethoxy)-3-methylpicolinamide (5) and N-(2-((5aR,7S,9aR)-2-amino-7-methyl-5,5a,6,7-tetrahydro-4H-pyrano[3,4-d][1,3]oxazepin-9a(9H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide (4) | US9771379, Example 4 |
Type | Small organic molecule |
Emp. Form. | C19H21F2N5O4S |
Mol. Mass. | 453.463 |
SMILES | C[C@H]1C[C@H]2CCOC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1 |r,c:8| |
Structure |
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