Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase SYK |
---|
Ligand | BDBM339994 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay |
---|
IC50 | 1±n/a nM |
---|
Citation | Altman, MD; Cash, B; Ellis, JM; Maddess, ML; Northrup, AB; Otte, RD; Sun, B 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors US Patent US9775839 Publication Date 10/3/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase SYK |
---|
Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
|
|
|
BDBM339994 |
---|
n/a |
---|
Name | BDBM339994 |
Synonyms: | 5-{[(2R)-2-amino-3- methoxypropyl]amino}-3- (4-methoxy-1H-indol-2- yl)pyrazine-2- carboxamide | US9775839, 8.7 |
Type | Small organic molecule |
Emp. Form. | C18H22N6O3 |
Mol. Mass. | 370.4057 |
SMILES | COC[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2c(OC)cccc2[nH]1 |r| |
Structure |
|