| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysine-specific demethylase 4C |
|---|
| Ligand | BDBM296181 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | JMJD2C Assay |
|---|
| IC50 | <100±n/a nM |
|---|
| Citation |  Boloor, A; Kanouni, T; Stafford, JA; Veal, JM; Wallace, MB Histone demethylase inhibitors US Patent US10202381 Publication Date 2/12/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysine-specific demethylase 4C |
|---|
| Name: | Lysine-specific demethylase 4C |
|---|
| Synonyms: | GASC-1 protein | GASC1 | Gene amplified in squamous cell carcinoma 1 protein | JHDM3C | JMJD2C | JmjC domain-containing histone demethylation protein 3C | Jumonji domain-containing protein 2C | KDM4C | KDM4C_HUMAN | KIAA0780 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 119979.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9H3R0 |
|---|
| Residue: | 1056 |
|---|
| Sequence: | MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQC
YDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLE
RKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYF
GMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFL
RHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWID
YGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWL
QRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAV
KLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSI
SSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLE
PGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEV
LSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSS
NEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAK
CCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAV
AVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTC
AHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVM
AVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGS
NIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGER
KRQRVLSSRFKNEYVADPVYRTFLKSSFQKKCQKRQ
|
|
|
|---|
| BDBM296181 |
|---|
| n/a |
|---|
| Name | BDBM296181 |
|---|
| Synonyms: | 2-(1-piperidin-4-ylindol-5- yl)oxypyrido[3,4-d]pyrimidin-4-ol | US10112940, Example 104 | US10202381, Example 104 | US10208039, Example 104 | US10611763, Example 104 | US10815234, Example 104 | US11535616, Example 104 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19N5O2 |
|---|
| Mol. Mass. | 361.3972 |
|---|
| SMILES | Oc1nc(Oc2ccc3n(ccc3c2)C2CCNCC2)nc2cnccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
