| Reaction Details |
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 | Report a problem with these data |
| Target | Glucagon-like peptide 1 receptor |
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| Ligand | BDBM349748 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CHO GLP-1R Clone C6-Assay 2 |
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| EC50 | 33.0±n/a nM |
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| Citation |  Aspnes, GE; Bagley, SW; Curto, JM; Dowling, MS; Edmonds, D; Flanagan, ME; Futatsugi, K; Griffith, DA; Huard, K; Ingle, G; Jiao, W; Limberakis, C; Mathiowetz, AM; Piotrowski, DW; Ruggeri, RB GLP-1 receptor agonists and uses thereof US Patent US10208019 Publication Date 2/19/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucagon-like peptide 1 receptor |
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| Name: | Glucagon-like peptide 1 receptor |
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| Synonyms: | GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 53035.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43220 |
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| Residue: | 463 |
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| Sequence: | MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW
RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW
RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
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| BDBM349748 |
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| n/a |
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| Name | BDBM349748 |
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| Synonyms: | 2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-yl}-2-methylpiperazin-1-yl]methyl}-1-(1,3-oxazol-2-ylmethyl)-1H-benzimidazole-6-carboxylic acid | US10208019, Example 10A-18 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28ClFN6O4 |
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| Mol. Mass. | 591.033 |
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| SMILES | C[C@H]1CN(CCN1Cc1nc2ccc(cc2n1Cc1ncco1)C(O)=O)c1cccc(OCc2ccc(Cl)cc2F)n1 |
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| Structure | 
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