| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 alpha |
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| Ligand | BDBM354275 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| IC50 | 16.0±n/a nM |
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| Citation |  Fyfe, MC; Knaggs, M; Meghani, P; Thom, SM Kinase inhibitors US Patent US9796742 Publication Date 10/24/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 alpha |
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| Name: | Glycogen synthase kinase-3 alpha |
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| Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 50991.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49840 |
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| Residue: | 483 |
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| Sequence: | MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
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| BDBM354275 |
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| n/a |
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| Name | BDBM354275 |
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| Synonyms: | N-(4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylphosphoryl)phenyl)-1H-pyrazol-5-yl)ureido)-naphthalen-1-yl)oxy)pyridin-2-yl)-2-methoxyacetamide | US9796742, Example 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H37N6O5P |
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| Mol. Mass. | 640.6685 |
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| SMILES | COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(cc3)P(C)(C)=O)C(C)(C)C)c3ccccc23)ccn1 |
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| Structure | 
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