| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
|---|
| Ligand | BDBM354308 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| IC50 | 9.00±n/a nM |
|---|
| Citation |  Fyfe, MC; Knaggs, M; Meghani, P; Thom, SM Kinase inhibitors US Patent US9796742 Publication Date 10/24/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase SYK |
|---|
| Name: | Tyrosine-protein kinase SYK |
|---|
| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 72079.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43405 |
|---|
| Residue: | 635 |
|---|
| Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
|
|
|
|---|
| BDBM354308 |
|---|
| n/a |
|---|
| Name | BDBM354308 |
|---|
| Synonyms: | 1-(3-(tert-Butyl)-1-(3-((diethylphosphoryl)methyl)phenyl)-1H-pyrazol-5-yl)-3-(4-((2-((7-methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea | US9796742, Example 36 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C41H44N9O3P |
|---|
| Mol. Mass. | 741.8203 |
|---|
| SMILES | CCP(=O)(CC)Cc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(C)c4[nH]ncc4c3)n2)c2ccccc12)C(C)(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
