Reaction Details |
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Target | Tyrosine-protein kinase SYK |
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Ligand | BDBM354333 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Inhibition Assay |
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IC50 | 24.0±n/a nM |
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Citation | Fyfe, MC; Knaggs, M; Meghani, P; Thom, SM Kinase inhibitors US Patent US9796742 Publication Date 10/24/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase SYK |
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Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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BDBM354333 |
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n/a |
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Name | BDBM354333 |
Synonyms: | 1-(3-(tert-Butyl)-1-(3-((dimethylphosphoryl)methyl)phenyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-morpholinoethoxy)-5-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea | US9796742, Example 61 |
Type | Small organic molecule |
Emp. Form. | C44H48F3N8O5P |
Mol. Mass. | 856.8715 |
SMILES | CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OCCN5CCOCC5)cc(c4)C(F)(F)F)n3)c3ccccc23)n(n1)-c1cccc(CP(C)(C)=O)c1 |
Structure |
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