| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK |
|---|
| Ligand | BDBM352312 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assay |
|---|
| IC50 | 0.200±n/a nM |
|---|
| Citation |  Liu, Q; Watterson, SH; Ahmad, S; Tebben, AJ Indole carboxamide compounds US Patent US9802915 Publication Date 10/31/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase BTK |
|---|
| Name: | Tyrosine-protein kinase BTK |
|---|
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 76289.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q06187 |
|---|
| Residue: | 659 |
|---|
| Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
|
|
|
|---|
| BDBM352312 |
|---|
| n/a |
|---|
| Name | BDBM352312 |
|---|
| Synonyms: | (R)-4-(3-(but-2- ynamido)piperidin-1-yl)- 5-fluoro-2,3-dimethyl- 1H-indole-7-carboxamide | US9802915, Example 243 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21FN4O2 |
|---|
| Mol. Mass. | 356.394 |
|---|
| SMILES | Cc1[nH]c2c(cc(F)c(N3CCC[C@H](C3)NC(=O)C#C)c2c1C)C(N)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
