Reaction Details |
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Target | Histone deacetylase 8 |
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Ligand | BDBM65525 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme inhibition assay |
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IC50 | 1766±n/a nM |
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Citation | Zhang, L; Wang, X; Li, X; Zhang, L; Xu, W Discovery of a series of hydroximic acid derivatives as potent histone deacetylase inhibitors. J Enzyme Inhib Med Chem29:582-9 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 8 |
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Name: | Histone deacetylase 8 |
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
Type: | Enzyme |
Mol. Mass.: | 41749.60 |
Organism: | Homo sapiens (Human) |
Description: | Q9BY41 |
Residue: | 377 |
Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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BDBM65525 |
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n/a |
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Name | BDBM65525 |
Synonyms: | (S)-4-(3-(2-((4-fluorophenyl)amino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide (L3) |
Type | Small Organic Molecule |
Emp. Form. | C28H30FN5O5 |
Mol. Mass. | 535.5667 |
SMILES | ONC(=O)CCCCCNC(=O)c1ccc(NC(=O)N[C@H](C(=O)Nc2ccc(F)cc2)c2ccccc2)cc1 |
Structure |
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