| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM65547 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme inhibition assay |
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| IC50 | 1522±n/a nM |
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| Citation |  Zhang, L; Wang, X; Li, X; Zhang, L; Xu, W Discovery of a series of hydroximic acid derivatives as potent histone deacetylase inhibitors. J Enzyme Inhib Med Chem29:582-9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM65547 |
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| n/a |
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| Name | BDBM65547 |
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| Synonyms: | phenylglycine containing lead compound (4h) |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N3O5 |
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| Mol. Mass. | 385.4137 |
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| SMILES | CC(C)(C)OC(=O)NC(C(=O)Nc1ccc(cc1)C(=O)NO)c1ccccc1 |
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| Structure | 
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