Ki Summary

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Target

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Ligand

BDBM354688

Substrate/Competitor

n/a

Meas. Tech.

HTRF assay

IC50

5.5±n/a nM

Citation

Armani, E; Amari, G; Blackaby, W; Van De Poel, H; Baker-Glenn, C; Trivedi, N Aminoester derivatives US Patent US9809582 Publication Date 11/7/2017

More Info.:

Get all data from this article, Assay Method

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Name:

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Synonyms:

Type:

Protein

Mol. Mass.:

83318.87

Organism:

Homo sapiens (Human)

Description:

Q07343

Residue:

736

Sequence:

MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT

BDBM354688

n/a

Name

BDBM354688

Synonyms:

US9809582, Example 33 | US9809582, Example 36 | US9809582, Example 37

Type

Small organic molecule

Emp. Form.

C39H41Cl2N3O7S

Mol. Mass.

766.73

SMILES

COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CNC2CC(C2)(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)s1 |r,wU:10.22,wD:37.39,(-7.16,-9.05,;-5.82,-9.82,;-4.49,-9.05,;-3.16,-9.82,;-1.82,-9.05,;-1.82,-7.51,;-3.16,-6.74,;-4.49,-7.51,;-5.82,-6.74,;-7.16,-7.51,;-.49,-6.74,;.85,-7.51,;2.18,-6.74,;2.18,-5.2,;.85,-4.43,;3.51,-4.43,;4.85,-5.2,;6.18,-4.43,;4.85,-6.74,;3.51,-7.51,;3.51,-9.05,;-.49,-5.2,;-1.82,-4.43,;-3.16,-5.2,;-1.82,-2.89,;-3.07,-1.99,;-2.59,-.52,;-1.05,-.52,;-.28,.81,;-1.05,2.14,;-.28,3.48,;1.21,3.87,;.81,5.36,;-.68,4.96,;2.3,4.96,;3.38,6.05,;2.69,3.48,;4.18,3.08,;4.58,1.59,;6.07,1.19,;7.16,2.28,;6.76,3.77,;5.27,4.17,;6.36,3.08,;4.98,2.28,;.41,6.85,;1.5,7.94,;1.1,9.43,;-.39,9.82,;-1.48,8.74,;-1.08,7.25,;-.58,-1.99,)|

Structure