Reaction Details | |||
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Target | Fibroblast growth factor receptor 1 | ||
Ligand | BDBM287045 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Activity Assay | ||
IC50 | 7.40±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Fibroblast growth factor receptor 1 | |||
Name: | Fibroblast growth factor receptor 1 | ||
Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
Type: | Receptor | ||
Mol. Mass.: | 91861.70 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11362 | ||
Residue: | 822 | ||
Sequence: |
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BDBM287045 | |||
n/a | |||
Name | BDBM287045 | ||
Synonyms: | 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-((2-(2-methoxyethoxy)ethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 63 | US11078199, Cpd 63 | US9567334, Example 63 | US9815834, Compound 63 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H38Cl2N6O6 | ||
Mol. Mass. | 649.565 | ||
SMILES | COCCOCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-8.67,-7.7,;-8.67,-6.16,;-7.34,-5.39,;-7.34,-3.85,;-6,-3.08,;-6,-1.54,;-4.67,-.77,;-4.67,.77,;-3.33,1.54,;-3.33,3.08,;-2,3.85,;-.67,3.08,;.67,3.85,;2,3.08,;3.33,3.85,;3.33,5.39,;2,6.16,;4.67,6.16,;4.67,7.7,;3.33,8.47,;6,5.39,;6,3.85,;7.34,3.08,;8.67,3.85,;4.67,3.08,;4.67,1.54,;2,1.54,;3.33,.77,;.67,.77,;.67,-.77,;2,-1.54,;2,-3.08,;3.33,-3.85,;3.33,-5.39,;4.67,-6.16,;6,-5.39,;6,-3.85,;4.67,-3.08,;7.34,-6.16,;8.67,-5.39,;7.34,-7.7,;8.67,-8.47,;-.67,1.54,;-2,.77,)| | ||
Structure | ![]() |