Reaction Details | |||
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Target | Fibroblast growth factor receptor 1 | ||
Ligand | BDBM287038 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Activity Assay | ||
IC50 | 3.70±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Fibroblast growth factor receptor 1 | |||
Name: | Fibroblast growth factor receptor 1 | ||
Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
Type: | Receptor | ||
Mol. Mass.: | 91861.70 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11362 | ||
Residue: | 822 | ||
Sequence: |
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BDBM287038 | |||
n/a | |||
Name | BDBM287038 | ||
Synonyms: | 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-((2,2-difluoroethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 44 | US11078199, Cpd 44 | US9567334, Example 44 | US9815834, Compound 44 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H30Cl2F2N6O4 | ||
Mol. Mass. | 611.468 | ||
SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC(F)F)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.67,8.47,;4,7.7,;4,6.16,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;2.67,3.85,;2.67,5.39,;1.33,6.16,;1.33,3.08,;,3.85,;-1.33,3.08,;-2.67,3.85,;-4,3.08,;-4,1.54,;-5.33,.77,;-5.33,-.77,;-6.67,-1.54,;-6.67,-3.08,;-8,-.77,;-2.67,.77,;-1.33,1.54,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;1.33,1.54,;2.67,.77,)| | ||
Structure | ![]() |