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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 1 | ||
| Ligand | BDBM287077 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Activity Assay | ||
| IC50 | 2.60±n/a nM | ||
| Citation |  Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US9815834 Publication Date 11/14/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 1 | |||
| Name: | Fibroblast growth factor receptor 1 | ||
| Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
| Type: | Receptor | ||
| Mol. Mass.: | 91861.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11362 | ||
| Residue: | 822 | ||
| Sequence: |
| ||
| BDBM287077 | |||
| n/a | |||
| Name | BDBM287077 | ||
| Synonyms: | (S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-((1-hydroxypropan-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 83 | US11078199, Cpd 83 | US9567334, Example 83 | US9815834, Compound 83 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H34Cl2N6O5 | ||
| Mol. Mass. | 605.513 | ||
| SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H](C)CO)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |r,wU:19.20,(4,8.09,;2.67,7.31,;2.67,5.78,;4,5,;4,3.46,;5.33,2.69,;6.67,3.46,;2.67,2.69,;2.67,1.15,;1.33,3.46,;1.33,5,;,5.77,;,2.69,;-1.33,3.46,;-2.67,2.69,;-4,3.46,;-5.33,2.69,;-5.33,1.15,;-6.67,.38,;-6.67,-1.16,;-5.33,-1.93,;-8,-1.93,;-8,-3.47,;-4,.38,;-2.67,1.15,;-1.33,.38,;-1.33,-1.16,;,-1.93,;,-3.47,;1.33,-4.24,;1.33,-5.78,;2.67,-6.55,;4,-5.78,;4,-4.24,;2.67,-3.47,;5.33,-6.55,;5.33,-8.09,;6.67,-5.78,;8,-6.55,;,1.15,;1.33,.38,)| | ||
| Structure | 
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