Ki Summary

Reaction Details

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Target

Fibroblast growth factor receptor 1

Ligand

BDBM287526

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Activity Assay

IC50

1.000±n/a nM

Citation

Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US9815834 Publication Date 11/14/2017

More Info.:

Get all data from this article, Assay Method

Fibroblast growth factor receptor 1

Name:

Fibroblast growth factor receptor 1

Synonyms:

Type:

Receptor

Mol. Mass.:

91861.70

Organism:

Homo sapiens (Human)

Description:

P11362

Residue:

822

Sequence:

MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD
ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD
KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF
PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

BDBM287526

n/a

Name

BDBM287526

Synonyms:

(R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-((1-methoxypropan-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 116 | US11078199, Cpd 116 | US9567334, Example 116 | US9815834, Compound 116

Type

Small organic molecule

Emp. Form.

C28H34Cl2N6O5

Mol. Mass.

605.513

SMILES

COC[C@@H](C)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CN(C3)C(=O)C=C)c2n1 |r,wD:3.3,(-8.28,-4.46,;-6.94,-3.69,;-6.94,-2.15,;-5.61,-1.38,;-4.28,-2.15,;-5.61,.16,;-4.28,.93,;-4.28,2.47,;-2.94,3.24,;-1.61,2.47,;-.28,3.24,;1.06,2.47,;2.39,3.24,;2.39,4.78,;1.06,5.55,;3.72,5.55,;3.72,7.09,;5.06,7.86,;5.06,4.78,;5.06,3.24,;6.39,2.47,;7.73,3.24,;3.72,2.47,;3.72,.93,;1.06,.93,;2.39,.16,;-.28,.16,;-.28,-1.38,;1.06,-2.15,;1.06,-3.69,;-.28,-4.46,;2.39,-4.46,;2.79,-5.95,;4.28,-5.55,;3.88,-4.06,;5.61,-6.32,;5.61,-7.86,;6.94,-5.55,;8.28,-6.32,;-1.61,.93,;-2.94,.16,)|

Structure