Reaction Details | |||
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Target | Lysine-specific histone demethylase 1A | ||
Ligand | BDBM254586 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biological Assays-Inhibition of LSD1 | ||
IC50 | 32.0±n/a nM | ||
Citation | Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martinez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US10214477 Publication Date 2/26/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Lysine-specific histone demethylase 1A | |||
Name: | Lysine-specific histone demethylase 1A | ||
Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) | ||
Type: | Enzyme | ||
Mol. Mass.: | 92901.01 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60341 | ||
Residue: | 852 | ||
Sequence: |
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BDBM254586 | |||
n/a | |||
Name | BDBM254586 | ||
Synonyms: | US10214477, Example 45 | US9469597, 45 | US9670136, 45 3-(5-((trans)-2-((4-aminocyclohexyl)amino)cyclopropyl)thiazol-2-yl)phenol | ||
Type | Small organic molecule | ||
Emp. Form. | C18H23N3OS | ||
Mol. Mass. | 329.46 | ||
SMILES | NC1CCC(CC1)N[C@H]1C[C@@H]1c1cnc(s1)-c1cccc(O)c1 |r,wU:10.12,wD:8.8,(6.65,5.12,;5.31,4.35,;5.31,2.81,;3.98,2.04,;2.64,2.81,;2.64,4.35,;3.98,5.12,;1.31,2.04,;-.02,2.81,;-.79,4.15,;-1.56,2.81,;-2.9,2.04,;-4.36,2.52,;-5.27,1.27,;-4.36,.03,;-2.9,.5,;-4.76,-1.46,;-6.25,-1.86,;-6.65,-3.35,;-5.56,-4.43,;-4.07,-4.04,;-2.98,-5.12,;-3.67,-2.55,)| | ||
Structure |