| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM357153 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kallikrein Assay |
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| Ki | 0.260±n/a nM |
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| Citation |  Xu, J; Ali, A; Zhou, W; Gao, Y; Edmondson, SD; Mertz, E; Neelamkavil, SF; Liu, W; Sun, W; Shen, D; Harper, B; Zhu, C; Bara, T; Lim, Y; Yang, M Factor XIA inhibitors US Patent US10214512 Publication Date 2/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM357153 |
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| n/a |
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| Name | BDBM357153 |
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| Synonyms: | (Z)-5-(3-Chloro-2,6-difluorophenyl)-2-(15-ethyl-24-((Methoxycarbonyl)amino)-4-oxo-11H-3-AZA-1(4,2)-imidazola-2(1,2) -benzenacyclononaphane-9-yl)pyridine 1-oxide | US10214512, Example 112-a |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28ClF2N5O4 |
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| Mol. Mass. | 596.024 |
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| SMILES | CCc1[nH]c2nc1-c1ccc(NC(=O)OC)cc1NC(=O)CCCCC2c1ccc(c[n+]1[O-])-c1c(F)ccc(Cl)c1F |
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| Structure | 
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