Reaction Details |
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Target | Methionine aminopeptidase |
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Ligand | BDBM17853 |
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Substrate/Competitor | Met-Gly-Met-Met |
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Meas. Tech. | EcMAP Enzyme Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 303.15±n/a K |
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IC50 | 250±n/a nM |
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Citation | Evdokimov, AG; Pokross, M; Walter, RL; Mekel, M; Barnett, BL; Amburgey, J; Seibel, WL; Soper, SJ; Djung, JF; Fairweather, N; Diven, C; Rastogi, V; Grinius, L; Klanke, C; Siehnel, R; Twinem, T; Andrews, R; Curnow, A Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins66:538-46 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Methionine aminopeptidase |
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Name: | Methionine aminopeptidase |
Synonyms: | EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map |
Type: | Enzyme |
Mol. Mass.: | 29326.96 |
Organism: | Escherichia coli (strain K12) |
Description: | Full-length untagged EcMAP was expressed in E. coli. |
Residue: | 264 |
Sequence: | MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACL
GYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTI
MGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEE
PQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVV
TDNGCEILTLRKDDTIPAIISHDE
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BDBM17853 |
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Met-Gly-Met-Met |
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Name: | Met-Gly-Met-Met |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 468.65 |
Organism: | n/a |
Description: | n/a |
Residue: | 4 |
Sequence: | |