| Reaction Details |
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 | Report a problem with these data |
| Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Ligand | BDBM275095 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibitory Test of TNAP Activity |
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| IC50 | 43.4±n/a nM |
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| Citation |  Miyazaki, S; Yamamoto, Y; Suzuki, K; Inui, M; Izumi, M; Soma, K; Pinkerton, A; Shinozaki, T Pyridine compounds US Patent US10221195 Publication Date 3/5/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Alkaline phosphatase, tissue-nonspecific isozyme |
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| Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57306.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1448917 |
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| Residue: | 524 |
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| Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
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| BDBM275095 |
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| n/a |
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| Name | BDBM275095 |
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| Synonyms: | US10221195, Example 37 | US9879032, Example 37 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18ClN3O5S |
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| Mol. Mass. | 459.903 |
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| SMILES | COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OCCN(c3ccccc3)C(=O)c2c1 |
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| Structure | 
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