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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [342-460] | ||
| Ligand | BDBM363497 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | AlphaScreen Assay | ||
| IC50 | <200±n/a nM | ||
| Citation |  Combs, AP; Yue, EW; Maduskuie, TP Tricyclic heterocycles as BET protein inhibitors US Patent US9850257 Publication Date 12/26/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [342-460] | |||
| Name: | Bromodomain-containing protein 4 [342-460] | ||
| Synonyms: | BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 13783.81 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | a.a. 342-460 (BRD4-BD2) | ||
| Residue: | 119 | ||
| Sequence: |
| ||
| BDBM363497 | |||
| n/a | |||
| Name | BDBM363497 | ||
| Synonyms: | US9850257, Example 4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H17N3O2 | ||
| Mol. Mass. | 331.3679 | ||
| SMILES | Cc1noc(C)c1-c1ccc2cnn3C(COc1c23)c1ccccc1 |(.13,-2.42,;1.47,-3.19,;1.94,-4.65,;3.48,-4.65,;3.96,-3.19,;5.29,-2.42,;2.71,-2.28,;2.71,-.74,;4.04,.03,;4.04,1.57,;2.71,2.34,;2.71,3.88,;.04,3.88,;.04,2.34,;-1.29,1.57,;-1.29,.03,;.04,-.74,;1.38,.03,;1.38,1.57,;-2.62,2.34,;-2.62,3.88,;-3.96,4.65,;-5.29,3.88,;-5.29,2.34,;-3.96,1.57,)| | ||
| Structure | 
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