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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [49-170] | ||
| Ligand | BDBM363502 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | AlphaScreen Assay | ||
| IC50 | 600±n/a nM | ||
| Citation |  Combs, AP; Yue, EW; Maduskuie, TP Tricyclic heterocycles as BET protein inhibitors US Patent US9850257 Publication Date 12/26/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [49-170] | |||
| Name: | Bromodomain-containing protein 4 [49-170] | ||
| Synonyms: | BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 14593.14 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | aa 49-170 (BRD4-BD1) | ||
| Residue: | 122 | ||
| Sequence: |
| ||
| BDBM363502 | |||
| n/a | |||
| Name | BDBM363502 | ||
| Synonyms: | US9850257, Example 9 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H16BrN3O2 | ||
| Mol. Mass. | 410.264 | ||
| SMILES | Cc1noc(C)c1-c1cc(Br)c2cnn3C(COc1c23)c1ccccc1 |(.09,-2.42,;1.42,-3.19,;1.9,-4.65,;3.44,-4.65,;3.91,-3.19,;5.25,-2.42,;2.67,-2.28,;2.67,-.74,;4,.03,;4,1.57,;5.33,2.34,;2.67,2.34,;2.67,3.88,;,3.88,;,2.34,;-1.33,1.57,;-1.33,.03,;,-.74,;1.33,.03,;1.33,1.57,;-2.67,2.34,;-2.67,3.88,;-4,4.65,;-5.33,3.88,;-5.33,2.34,;-4,1.57,)| | ||
| Structure | 
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