| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor beta |
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| Ligand | BDBM19932 |
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| Substrate/Competitor | BDBM17289 |
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| Meas. Tech. | Competition-Based Ligand Binding Assay and Transactivation Assay. |
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| IC50 | 3224±n/a nM |
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| Citation |  Güngör, T; Chen, Y; Golla, R; Ma, Z; Corte, JR; Northrop, JP; Bin, B; Dickson, JK; Stouch, T; Zhou, R; Johnson, SE; Seethala, R; Feyen, JH Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazolinethione derivatives as selective estrogen receptor beta modulators. J Med Chem49:2440-55 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Estrogen receptor beta |
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| Name: | Estrogen receptor beta |
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| Synonyms: | ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta |
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| Type: | Protein |
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| Mol. Mass.: | 59238.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92731 |
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| Residue: | 530 |
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| Sequence: | MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
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| BDBM19932 |
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| BDBM17289 |
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| Name | BDBM19932 |
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| Synonyms: | 3-arylquinazolinone, 1ax | 5,7-dihydroxy-3-(4-hydroxyphenyl)-2-propyl-3,4-dihydroquinazolin-4-one |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N2O4 |
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| Mol. Mass. | 312.3199 |
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| SMILES | CCCc1nc2cc(O)cc(O)c2c(=O)n1-c1ccc(O)cc1 |
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| Structure | 
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